期刊
NATURAL PRODUCT RESEARCH
卷 28, 期 12, 页码 914-916出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2014.889133
关键词
Centipeda minima L; isobutyroylplenolin; arnicolide D; cytotoxic; reactive oxygen species; nuclear factor-B
资金
- Grants-in-Aid for Scientific Research [25242013] Funding Source: KAKEN
In this study, we found that two sesquiterpene lactones, isobutyroylplenolin and arnicolide D, from Centipeda minima L. (Compositae) exerted stronger cytotoxic activity than cisplatin on the human colon carcinoma HT-29 cell line. Furthermore, the cytotoxicity of these two compounds on normal cells was weaker than that of cisplatin. Treatment with isobutyroylplenolin and arnicolide D increased the levels of intracellular reactive oxygen species and decreased the levels of nuclear factor-B protein, resulting in cell cycle arrest in G1 phase and apoptosis. We also discuss the difference in structure and activity between these two compounds.
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