期刊
NATURAL PRODUCT RESEARCH
卷 29, 期 3, 页码 247-252出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2014.971790
关键词
Uvaria rufa; Annonaceae; lignan glycoside; ufaside; cytotoxicity
资金
- Hue University (Vietnam) [DHH2014-04-35]
Chemical investigation of the aerial parts of Uvaria rufa (Dunal) Blume collected from Vietnam yielded one new lignan glycoside, ufaside (1), along with six known compounds, oxoanolobine (2), ergosta-4,6,8(14),22-tetraen-3-one (3), catechin (4), epicatechin (5), daucosterol (6) and glutin-5-en-3-one (7). Their chemical structures were determined by using NMR, HR-MS spectroscopic analyses and in comparison with the reported data. A cytotoxic analysis of U. rufa herb extracts was performed for the first time using nine human cancer cell lines (MCF-7, MDA-MB-231, LNCaP, MKN7, SW480, KB, LU-1, HepG2 and HL-60) derived from different tumour types. Of these seven constituents, compounds 2 and 3 displayed moderate cytotoxicity against the human lung adenocarcinoma cell line (LU-1) with IC50 values of 9.22 +/- 1.02 mu g/mL and 10.21 +/- 1.16 mu g/mL, respectively.
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