期刊
NATURAL PRODUCT RESEARCH
卷 28, 期 20, 页码 1772-1776出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2014.931391
关键词
Scutellaria baicalensis Georgi; flavone glycosides; wogonin 7-O-beta-D-ethylglucuronide; aitilipid-peroxidation; cytoprotective
资金
- National New Drug Innovation Major Project of China [2011ZX09307-002-02]
- Qing Lan Project of Jiangsu Province
A new flavone glycoside, wogonin 7-O-beta-D-ethylglucuronide (1), together with a new natural flavone glycoside baicalein 7-O-beta-D-ethylglucuronide (2) and four known analogues, wogonoside (3), wogonin (4), oroxylin A 7-O-beta-D-methylglucuronide (5) and oroxylin A (6), was isolated from the roots of Scutellaria baicalensis Georgi. The structure elucidation of the new compound was primarily based on HR-ESI-MS, 1D and 2D NMR analyses. Compounds 1 and 3 inhibited FeSO4-Cys-induced liver homogenate lipid peroxidation with IC50 at 18.2 mu M and 24.9 mu M, respectively, and exhibited strong cytoprotective effects against H2O2-induced oxidative damage in human umbilical vein endothelial cells at low concentrations of 10.0 mu M and 3.0 mu M.
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