期刊
NATURAL PRODUCT RESEARCH
卷 27, 期 18, 页码 1611-1619出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2012.742079
关键词
Lentinus polychrous Lev; sterol; estrogenic activity; anti-estrogenic activity; oestrogen receptor
资金
- Office of the Higher Education Commission, Thailand
- Center of Research and Development of Herbal Health Products, Khon Kaen University, Thailand
- Laboratory of Pharmacognosy, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
From mycelia of Lentinus polychrous, a Thai local edible mushroom cultured under solid-state fermentation, a new compound, 6-methylheptane-1,2,3,4,5-pentaol (1), and five ergostanoids, namely (22E,24R)-ergosta-7,22-dien-3,5,6-triol (2), 3,5-dihydroxy-(22E,24R)-ergosta-7,22-dien-6-one (3), ergosta-4,6,8(14),22-tetraen-3-one (4), (3,5,8,22E)-5,8-diepoxy-ergosta-6,22-dien-3-ol (5) and 5,8-epidioxy-(3,5,8,22E)-ergosta-6,9(11),22-trien-3-ol (6), was isolated and characterised. The compounds were determined for their oestrogenic and anti-oestrogenic activities by using human breast cancer T47D cells. All compounds had no oestrogenic activity but exhibited suppressive effect on oestradiol-enhanced cell proliferation. Among these compounds, only 4 significantly competed with oestradiol in the binding to oestrogen receptors (ERs) with higher selectivity to ER than ER. These results may suggest that most compounds suppressed this oestradiol-enhanced T47D proliferation via other mechanisms rather than ER binding.
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