期刊
NATURAL PRODUCT RESEARCH
卷 27, 期 23, 页码 2161-2167出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2013.793688
关键词
marine Streptomyces antibioticus; indanomycin-related antibiotics; NMR data; antibacterial activity
资金
- National Science Foundation of China [81273428]
- Cross-Disciplinary Research for Ocean Science of Zhejiang University [2012HY018B]
Four indanomycin-related antibiotics 2-5 were isolated from the cultured broth of marine Streptomyces antibioticus strain PTZ0016. Their structures were characterised as 16-deethylindanomycin (2), iso-16-deethylindanomycin (3), 16-deethylindanomycin methyl ester (4) and iso-16-deethylindanomycin methyl ester (5) on the basis of NMR, HR-ESI-MS and CD evidences. Compounds 3-5 are new additions to the class of indanomycin antibiotics. All isolated compounds showed in vitro activity against Staphylococcus aureus with minimal inhibitory concentration at 4.0-8.0g/ml.
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