期刊
NATURAL PRODUCT RESEARCH
卷 27, 期 18, 页码 1691-1694出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2012.763127
关键词
chemical constituent; Dianthus superbus; cytotoxicity
资金
- National Natural Science Foundation of China [30970294, 31070317]
The ethyl acetate fraction (EE-DS) from Dianthus superbus was found to possess the cytotoxic activity against cancer cells in previous study. To investigate cytotoxic constituents, the bioassay-guided isolation of compounds from EE-DS was performed. Two dianthramides (1 and 2), three flavonoids (3-5), two coumarins (6 and 7) and three other compounds (8-10) were obtained. Structures of isolated compounds were identified by spectroscopic analysis. Cytotoxicity of the compounds against HepG2 cells was evaluated. Compound 1 showed the strongest cytotoxicity, compounds 10, 4, 3 and 5 had moderate cytotoxicity.
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