期刊
NATURAL PRODUCT RESEARCH
卷 27, 期 12, 页码 1060-1066出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2012.708659
关键词
Aspergillus terreus; Laurencia ceylanica; butyrolactone; 3-hydroxy-4-(4-hydroxyphenyl)-5-methoxycarbonyl-5-(4-hydroxy-3-formylbenzyl)-2; 5-dihydro-2-furanone; -glucuronidase
资金
- Third World Academy of Science (TWAS), Trieste, Italy
An endophytic fungus Aspergillus terreus, var. boedijnii (Blochwitz) was isolated from red marine alga Laurencia ceylanica, J. Agardh, cultured in large scale and extracted with EtOAc. The above-mentioned extract yielded a new butyrolactone, 3-hydroxy-4-(4-hydroxyphenyl)-5-methoxycarbonyl-5-(4-hydroxy-3-formylbenzyl)-2,5-dihydro-2-furanone (1), along with the previously reported nine compounds, butyrolactone-1 (2), 6-hydroxymellin (3), (3R, 4R)-6,7-dimethoxy-4-hydroxymellin (4), (+)-territonin (5), (+)-territonin-A (6), (+)-asterrelenin (7), (+)-terrein (8), oleic acid (9) and glucopyranosyl--sitosterol (10), on column and preparative thin-layer chromatography. Compounds 1-8 were subjected to -glucuronidase inhibitory activity test, and 1 showed a remarkable activity, while 2 and 7 showed moderate activity.
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