期刊
NATURAL PRODUCT RESEARCH
卷 27, 期 4-5, 页码 340-349出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2012.693924
关键词
aromadendrine; flavonoids; dihydroflavonol; Olea europaea
资金
- University of Roma 'La Sapienza'
- University of Catania
- MIUR (Ministry of University)
- BIONAP S.r.l. (S. Venerina, Catania)
Leaves of Olea europaea, cultivar Nocellara del Belice, were examined with respect to the medium-polar fraction, obtained by an ethyl acetate extraction of the whole extract. In the medium polar fraction, we isolated the two hydroxy-phenyl-ethyl alcohols (hydroxyl-tyrosol and tyrosol) that are the main component of olives. In addition, we isolated a flavonoidic compound, aromadendrine, a dihydroflavonol yet known but quite rare in nature. It is the first time that aromadendrine is isolated in O. europaea and we studied the aromadendrine biological activity. In particular, the ability of aromadendrine to reduce the inflammation induced in normal keratinocytes using an invitro cell model was evaluated. The results of the present research indicate aromadendrine as a novel component in O. europaea with effective activity against skin inflammation.
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