期刊
NATURAL PRODUCT RESEARCH
卷 26, 期 18, 页码 1746-1749出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2011.608675
关键词
anti-inflammatory activity; acne; cytokines; Chinese medicinal herbs
资金
- State Key Laboratory of Bioreactor Engineering
Interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha) from keratinocyte play important roles in initiating the inflammatory process of acne. They are used as major elements to evaluate the anti-inflammatory activity of drugs. In this study, various active constituents extracted from Chinese medicinal herbs were tested for their anti-inflammatory effects against P. acnes using ELISA. Among the constituents, matrine, baicalin, ursolic acid, sodium danshensu, magnolol, honokiol, hesperidin and andrographolide significantly reduced IL-8 and TNF-alpha by human HaCaT keratinocyte cells pretreated with heat-killed P. acnes. Excepting hesperidin, these active constituents presented dose-dependent inhibitory effects. Our studies showed that all of them exhibited low cytotoxicity at 5 mu g mL(-1) in tested cell lines, and even at 50 mu g mL(-1), in the cases of matrine, baicalin, ursolic acid and sodium danshensu. Based on the obtained results, it can be suggested that these active constituents are potential acne-mitigating candidates for cosmetic applications.
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