期刊
NATURAL PRODUCT RESEARCH
卷 25, 期 15, 页码 1418-1422出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786410802496911
关键词
Corydalis yanhusuo; acetylcholinesterase; isoquinoline alkaloids
资金
- Natural Science Foundation of Guizhou Province [20052068, 20033048]
- Special Fund for Excellent Scholars in Education, Science and Technology of the Guizhou Provincial Governor
In a bioassay-guided search for acetylcholinesterase (AChE) inhibitors from Chinese natural resources, eight isoquinoline alkaloids, tetrahydropalmatine (1), corydaline (2), protopine (3), berberine (4), palmatine (5), jatrorrhizine (6), coptisine (7) and dehydrocorydaline (8), were isolated from the methanolic extract of the tubers of Corydalis yanhusuo. Structures of these compounds were identified by spectroscopic techniques. Compounds 4-8 inhibited AChE activity in a dose-dependent manner, and the IC50 values were 0.47 +/- 0.01, 0.74 +/- 0.06, 2.08 +/- 0.09, 1.01 +/- 0.03 and 0.62 +/- 0.05 mu M, respectively. Structure-activity relationship analysis suggested that aromatisation at ring C, as well as substitutions at C-2, C-3, C-9, C-10 and C-13 affect the AChE activity of protoberberine alkaloids.
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