期刊
NATURAL PRODUCT RESEARCH
卷 24, 期 1, 页码 81-85出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786410902836701
关键词
marine fungi; secondary metabolite; anthraquinone
资金
- National Natural Science Foundation of China [40776073, 20072058]
- Syngenta Limited, UK
A new anthraquinone compound, 5-acetyl-2-methoxy-1,4,6-trihydroxy-anthraquinone (1), together with four known naphthoquinones (2-5), were isolated from the culture of the mangrove fungus (No. b77). All the isolated compounds (1-5) and the acetyl derivative (1a) were established by comprehensive analysis of the spectral data, especially 1D- and 2D-NMR (HMQC and HMBC) spectra. In the primary bioassays, compound 3 showed strong inhibitory effects on the growth of hepG2 and hep2 cells, with IC50 values of 1.0 and 2.5 mu g mL(-1), respectively.
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