期刊
NATURAL PRODUCT REPORTS
卷 31, 期 8, 页码 1056-1073出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4np00007b
关键词
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资金
- Ministry of Education, Culture, Sports, Science, Science and Technology (MEXT)
- Nagase Science and Technology Foundation
- Takeda Science Foundation
- Grants-in-Aid for Scientific Research [25850050, 22108003] Funding Source: KAKEN
We focus here on beta-amino acids as components of complex natural products because the presence of beta-amino acids produces structural diversity in natural products and provides characteristic architectures beyond those of ordinary alpha-L-amino acids, thus generating significant and unique biological functions in nature. In this review, we first survey the known bioactive beta-amino acid-containing natural products including nonribosomal peptides, macrolactam polyketides, and nucleoside-beta-amino acid hybrids. Next, the biosynthetic enzymes that form beta-amino acids from beta-amino acids and the de novo synthesis of beta-amino acids are summarized. Then, the mechanisms of beta-amino acid incorporation into natural products are reviewed. Because it is anticipated that the rational swapping of the beta-amino acid moieties with various side chains and stereochemistries by biosynthetic engineering should lead to the creation of novel architectures and bioactive compounds, the accumulation of knowledge regarding beta-amino acid-containing natural product biosynthetic machinery could have a significant impact in this field. In addition, genome mining of characteristic beta-amino acid biosynthetic genes and unique beta-amino acid incorporation machinery could lead to the discovery of new beta-amino acid-containing natural products.
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