期刊
NATURAL PRODUCT REPORTS
卷 30, 期 8, 页码 1121-1138出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3np70034h
关键词
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资金
- Australian Research Council [FF0883440]
- Deutsche Forschungsgemeinschaft
- Deutsches Zentrum fur Infektionsforschung Standort Hannover-Braunschweig
- Bundesministerium fur Bildung und Forschung
- Australian Research Council [FF0883440] Funding Source: Australian Research Council
The heterologous expression of microbial natural product biosynthetic pathways coupled with advanced DNA engineering enables optimisation of product yields, functional elucidation of cryptic gene clusters, and generation of novel derivatives. This review summarises the recent advances in cloning and maintenance of natural product biosynthetic gene clusters for heterologous expression and the efforts fundamental for discovering novel natural products in the post-genomics era, with a focus on polyketide synthases (PKSs) and non-ribosomal polypeptide synthetases (NRPS).
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