期刊
NATURAL PRODUCT REPORTS
卷 30, 期 6, 页码 765-782出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3np70016j
关键词
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资金
- China Scholarship Council
- French Ministry of Research
- Agence Nationale de la Recherche [ANR-12-BS07-0028-01 SYNBIORG]
- CNRS
- MNHN (ATM)
Fungal polyketides and their hybrid non ribosomal peptide derivatives are characterized by often striking structural features and biological activities. Their diversity and their complexity arise from highly organized and programmable biosynthetic pathways and have been challenged by many synthetic chemists. This review will conceptually illustrate how complexity can be generated, starting from a general biosynthetic purpose (the fundaments of PKS-NRPS assembly lines) and finally showing how the particular class of hirsutellone compounds has emerged from such processes in relation to post-elongation and secondary tailoring events. Synthetic efforts to produce these natural products will be described with a special emphasis on complexity-generating strategies and steps. Thus, the biosynthetic and synthetic works will be analyzed in a continuous flow, focusing on both the logic of Nature and organic chemists.
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