期刊
NATURAL PRODUCT REPORTS
卷 29, 期 10, 页码 1111-1137出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2np20062g
关键词
-
资金
- BBSRC [BB/F014570/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/F014570/1] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [BB/F014570/1] Funding Source: researchfish
Common to all FASs, PKSs and NRPSs is a remarkable component, the acyl or peptidyl carrier protein (A/PCP). These take the form of small individual proteins in type II systems or discrete folded domains in the multi-domain type I systems and are characterized by a fold consisting of three major a-helices and between 60-100 amino acids. This protein is central to these biosynthetic systems and it must bind and transport a wide variety of functionalized ligands as well as mediate numerous protein-protein interactions, all of which contribute to efficient enzyme turnover. This review covers the structural and biochemical characterization of carrier proteins, as well as assessing their interactions with different ligands, and other synthase components. Finally, their role as an emerging tool in biotechnology is discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据