期刊
NATURAL PRODUCT REPORTS
卷 29, 期 6, 页码 683-696出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2np20021j
关键词
-
资金
- National Institutes of Health [CA70375, CA55254]
- NATIONAL CANCER INSTITUTE [R01CA055254, R37CA055254, R01CA070375] Funding Source: NIH RePORTER
The biosynthesis of the anti-cancer drug taxol (paclitaxel) has required the collaborative efforts of several research groups to tackle the synthesis and labeling of putative biosynthetic intermediates, in concert with the identification, cloning and functional expression of the biosynthetic genes responsible for the construction of this complex natural product. Based on a combination of precursor labeling and incorporation experiments, and metabolite isolation from Taxus spp., a picture of the complex matrix of pathway oxygenation reactions following formation of the first committed intermediate, taxa-4(5), 11(12)-diene, is beginning to emerge. An overview of the current state of knowledge on the early-stages of taxol biosynthesis is presented.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据