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BIOTECHNOLOGY LETTERS (2004)
Iteration as programmed event during polyketide assembly; molecular analysis of the aureothin biosynthesis gene cluster
J He et al.
CHEMISTRY & BIOLOGY (2003)
Where will new antibiotics come from?
C Walsh
NATURE REVIEWS MICROBIOLOGY (2003)
Why is big Pharma getting out of antibacterial drug discovery?
SJ Projan
CURRENT OPINION IN MICROBIOLOGY (2003)
Integration site for streptomyces phage φBT1 and development of site-specific integrating vectors
MA Gregory et al.
JOURNAL OF BACTERIOLOGY (2003)
Engineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli
K Watanabe et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Rapid engineering of polyketide overproduction by gene transfer to industrially optimized strains
E Rodriguez et al.
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2003)
Enhanced heterologous polyketide production in Streptomyces by exploiting plasmid co-integration
ZH Hu et al.
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2003)
Engineering a mevalonate pathway in Escherichia coli for production of terpenoids
VJJ Martin et al.
NATURE BIOTECHNOLOGY (2003)
Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp.: AM-7161:: towards comparative analysis of the benzoisochromanequinone gene clusters
K Ichinose et al.
MICROBIOLOGY-SGM (2003)
PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin
B Gust et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
A genomics-guided approach for discovering and expressing cryptic metabolic pathways
E Zazopoulos et al.
NATURE BIOTECHNOLOGY (2003)
Heterologous expression in Saccharopolyspora erythraea of a pentaketide synthase derived from the spinosyn polyketide synthase
CJ Martin et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2003)
Biosynthesis of yersiniabactin, a complex polyketide-nonribosomal peptide, using Escherichia coli as a heterologous host
BA Pfeifer et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2003)
Molecular cloning and heterologous expression of the C-13 phenylpropanoid side chain-CoA acyltransferase that functions in Taxol biosynthesis
K Walker et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Metabolic engineering towards biotechnological production of carotenoids in microorganisms
PC Lee et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2002)
Inactivation, complementation, and heterologous expression of encP, a novel bacterial phenylalanine ammonia-lyase gene
LK Xiang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Conditionally amplifiable BACs: Switching from single-copy to high-copy vectors and genomic clones
J Wild et al.
GENOME RESEARCH (2002)
A gene cluster from a marine Streptomyces encoding the biosynthesis of the aromatic spiroketal polyketide griseorhodin A
AY Li et al.
CHEMISTRY & BIOLOGY (2002)
Heterologous expression of epothilone biosynthetic genes in Myxococcus xanthus
B Julien et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2002)
Heterologous production of two unusual acyclic carotenoids, 1,1′-dihydroxy-3,4-didehydrolycopene and 1-hydroxy-3,4,3′,4′-tetradehydrolycopene by combination of the crtC and crtD genes from Rhodobacter and Rubrivivax
S Steiger et al.
JOURNAL OF BIOTECHNOLOGY (2002)
The final acylation step in Taxol biosynthesis:: Cloning of the taxoid C13-side-chain N-benzoyltransferase from Taxus
K Walker et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus
RL Arslanian et al.
JOURNAL OF NATURAL PRODUCTS (2002)
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
SD Bentley et al.
NATURE (2002)
Isolation and characterization of two germacrene A synthase cDNA clones from chicory
HJ Bouwmeester et al.
PLANT PHYSIOLOGY (2002)
Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae
YJ Yoon et al.
CHEMISTRY & BIOLOGY (2002)
Saccharopolyspora erythraea-catalyzed bioconversion of 6-deoxyerythronolide B analogs for production of novel erythromycins
C Carreras et al.
JOURNAL OF BIOTECHNOLOGY (2002)
Strategies for the transformation of filamentous fungi
B Ruiz-Diez
JOURNAL OF APPLIED MICROBIOLOGY (2002)
The in vivo synthesis of plant sesquiterpenes by Escherichia coli
VJJ Martin et al.
BIOTECHNOLOGY AND BIOENGINEERING (2001)
Taxol biosynthesis:: Taxane 13α-hydroxylase is a cytochrome P450-dependent monooxygenase
S Jennewein et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Genome sequence of an industrial microorganism Streptomyces avermitilis:: Deducing the ability of producing secondary metabolites
S Omura et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Engineered biosynthesis of the peptide antibiotic bacitracin in the surrogate host Bacillus subtilis
K Eppelmann et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Engineering Escherichia coli for the synthesis of taxadiene, a key intermediate in the biosynthesis of taxol
QL Huang et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2001)
Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans
SE Wohlert et al.
CHEMISTRY & BIOLOGY (2001)
Techniques: Recombinogenic engineering - new options for cloning and manipulating DNA
JPP Muyrers et al.
TRENDS IN BIOCHEMICAL SCIENCES (2001)
Cloning and heterologous expression of the macrotetrolide biosynthetic gene cluster revealed a novel polyketide synthase that lacks an acyl carrier protein
HJ Kwon et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)
Biosynthesis of complex polyketides in a metabolically engineered strain of E-coli
BA Pfeifer et al.
SCIENCE (2001)
Molecular cloning of a cytochrome P450 taxane 10β-hydroxylase cDNA from Taxus and functional expression in yeast
A Schoendorf et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Carotenoid biosynthesis and biotechnological application
G Sandmann
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2001)
Heterologous expression of the naphthocyclinone hydroxylase gene from Streptomyces arenae for production of novel hybrid polyketides
P Brunker et al.
ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY (2001)
Genetic methods and strategies for secondary metabolite yield improvement in actinomycetes
RH Baltz
ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY (2001)
Taxol biosynthesis:: Molecular cloning of a benzoyl-CoA:taxane 2α-O-benzoyltransferase cDNA from Taxus and functional expression in Escherichia coli
K Walker et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Analysis of genes involved in 6-deoxyhexose biosynthesis and transfer in Saccharopolyspora erythraea
M Doumith et al.
MOLECULAR AND GENERAL GENETICS (2000)
Cloning, nucleotide sequence, and heterologous expression of the biosynthetic gene cluster for R1128, a non-steroidal estrogen receptor antagonist - Insights into an unusual priming mechanism
T Marti et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Identification of a cyclohexylcarbonyl CoA biosynthetic gene cluster and application in the production of doramectin
TA Cropp et al.
NATURE BIOTECHNOLOGY (2000)
Biosynthesis of the anti-parasitic agent megalomicin:: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea
Y Volchegursky et al.
MOLECULAR MICROBIOLOGY (2000)
Heterologous expression and characterization of a pseudomature form of taxadiene synthase involved in paclitaxel (Taxol) biosynthesis and evaluation of a potential intermediate and inhibitors of the multistep diterpene cyclization reaction
DC Williams et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2000)
One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
KA Datsenko et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Engineering novel carotenoids in microorganisms
C Schmidt-Dannert
CURRENT OPINION IN BIOTECHNOLOGY (2000)
Directed transfer of large DNA fragments between Streptomyces species
ZH Hu et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2000)
Molecular cloning of a taxa-4(20),11(12)-dien-5α-ol-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli
K Walker et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2000)
Formation of functional heterologous complexes using subunits from the picromycin, erythromycin and oleandomycin polyketide synthases
L Tang et al.
CHEMISTRY & BIOLOGY (2000)
Role of linkers in communication between protein modules
RS Gokhale et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2000)
Cloning and heterologous expression of the epothilone gene cluster
L Tang et al.
SCIENCE (2000)
Molecular cloning of a 10-deacetylbaccatin III-10-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli
K Walker et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Artificial chromosomes for antibiotic-producing actinomycetes
M Sosio et al.
NATURE BIOTECHNOLOGY (2000)
Elucidation of anthracyclinone biosynthesis by stepwise cloning of genes for anthracyclines from three different Streptomyces spp.
J Kantola et al.
MICROBIOLOGY-UK (2000)
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