期刊
NATURAL PRODUCT REPORTS
卷 25, 期 5, 页码 845-853出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b807243d
关键词
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资金
- NIH [GM081743]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [F32GM081743] Funding Source: NIH RePORTER
Polyketides are secondary metabolites biosynthesized by the iterative Claisen condensation of malonate units. Despite utilizing only a small set of biochemical transformations, the polyketide biosynthetic machinery yields products Of Striking structural complexity and diversity. Recently, a new polyketicle alkylation pathway was characterized that allows access to beta-branched structures. This Highlight will describe this alkylation sequence, with special emphasis on its parallels to isoprenoid biosynthesis from primary metabolism and the scope of structures accessible via this pathway.
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