期刊
NANOTOXICOLOGY
卷 8, 期 3, 页码 295-304出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/17435390.2013.778345
关键词
hatching enzyme; nanoparticle; hatch; ZHE1; protein interaction
资金
- Natural Sciences and Engineering Research Council (NSERC) Vanier Canadian Graduate Scholarship
- Alberta Innovates Graduate Student Scholarship
- NSERC
- NSERC-NRC-BDC-EC [RES0002319]
Aquatic organisms are susceptible to waterborne nanoparticles (NP) and there is only limited understanding of the mechanisms by which these emerging contaminants may affect biological processes. This study used silicon (nSi), cadmium selenide (nCdSe), silver (nAg) and zinc NPs (nZnO) as well as single-walled carbon nanotubes (SWCNT) to assess NP effects on zebrafish (Danio rerio) hatch. Exposure of 10 mg/L nAg and nCdSe delayed zebrafish hatch and 100 mg/L of nCdSe as well as 10 and 100 mg/L of uncoated nZnO completely inhibited hatch and the embryos died within the chorion. Both the morphology and the movement of the embryos were not affected, and it was determined that the main mechanism of hatch inhibition by NPs is likely through the interaction of NPs with the zebrafish hatching enzyme. Furthermore, it was concluded that the observed effects arose from the NPs themselves and not their dissolved metal components.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据