期刊
NANOTOXICOLOGY
卷 5, 期 4, 页码 700-710出版社
INFORMA HEALTHCARE
DOI: 10.3109/17435390.2010.550695
关键词
Welding fume; inhalation; lung burden; nanoparticles; pulmonary toxicity
资金
- National Institute for Occupational Safety and Health (NIOSH) [NIOSH IA 97-04-05M12]
- National Occupational Research Agenda (NORA)
The goal was to determine if increasing welding voltage changes the physico-chemical properties of the fume and influences lung responses. Rats inhaled 40 mg/m(3) (3 h/day x 3 days) of stainless steel (SS) welding fume generated at a standard voltage setting of 25 V (regular SS) or at a higher voltage (high voltage SS) of 30 V. Particle morphology, size and composition were characterized. Bronchoalveolar lavage was performed at different times after exposures to assess lung injury. Fumes collected from either of the welding conditions appeared as chain-like agglomerates of nanometer-sized primary particles. High voltage SS welding produced a greater number of ultrafine-sized particles. Fume generated by high voltage SS welding was higher in manganese. Pulmonary toxicity was more substantial and persisted longer after exposure to the regular SS fume. In summary, a modest raise in welding voltage affected fume size and elemental composition and altered the temporal lung toxicity profile.
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