期刊
NANOTOXICOLOGY
卷 6, 期 7, 页码 766-775出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/17435390.2011.620719
关键词
Nanomaterial; single-wall carbon nanotube; inhalation; dispersion
资金
- New Energy and Industrial (NEDO) [P06041]
Single-wall carbon nanotubes (SWCNTs) were well-dispersed by ultrasonication to conduct an inhalation study. SWCNTs were generated using a pressurised nebuliser with liquid suspension of SWCNTs. Wistar rats were exposed to the well-dispersed SWCNT (diameter of bundle: 0.2 mu m; length of bundle: 0.7 mu m) for 4 weeks. The low and high mass concentrations of SWCNTs were 0.03 +/- 0.003 and 0.13 +/- 0.03 mg/m(3), respectively. The rats were sacrificed at 3 days, 1 month, and 3 months after the end of exposure. There were no increases of total cell or neutrophil counts in the bronchoalveolar lavage fluid (BALF), or the concentration of cytokine-induced neutrophil chemoattractant in the lungs or BALF in both the high and low concentration-exposed groups. Pulmonary infiltration of neutrophils was not observed in either exposed group throughout the observation period. Well-dispersed SWCNT did not induce neutrophil inflammation in the lung under the conditions in the present study.
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