期刊
NANOTOXICOLOGY
卷 6, 期 7, 页码 736-745出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/17435390.2011.611915
关键词
Nanoparticles; cardiovascular diseases; titanium dioxide; inhalation study
The inhalation of engineered nanoparticles stimulates the development of atherosclerosis and impairs vascular function. However, the cardiac effects of inhaled engineered nanoparticles are unknown. Here, we investigate the effects of ultrafine titanium dioxide (UFTiO2) on the heart, and we define the possible mechanisms underlying the measured effects. Pulmonary exposure of rats to UFTiO2 increased the phosphorylation levels of p38 mitogen-activated protein kinase and cardiac troponin I, but not Akt, in the heart and substance P synthesis in nodose ganglia. Circulatory levels of pro-inflammatory cytokines, and blood cell counts and differentials were not significantly changed after pulmonary exposure. Separately, the incubation of cardiac myocytes isolated from naive adult rat hearts in vitro with UFTiO2 did not alter the phosphorylation status of the same cardiac proteins. In conclusion, the inhalation of UFTiO2 enhanced the phosphorylation levels of cardiac proteins. Such responses are likely independent of systemic inflammation, but may involve a lung-neuron-regulated pathway.
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