期刊
NANOTOXICOLOGY
卷 5, 期 2, 页码 140-156出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/17435390.2010.504311
关键词
AgNPs; synthetic alveolar lavage fluid; nanoparticle dispersion protocol; nanoEHS; SAXS flow cell
资金
- U. S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-06CH11357]
- National Science Foundation/Department of Energy [CHE-0535644]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0822838] Funding Source: National Science Foundation
The dispersion stabilization of silver nanoparticles (AgNPs) in synthetic lung fluid was studied to interrogate the effects on colloidal stability due to the principal constituents of the fluid. The colloidal stability of 20 nm citrate-AgNPs dispersed in the presence of each constituent of the synthetic lung fluid (individually, the complete fluid, and without additives) was observed during titration of increasing sodium chloride concentration. A variety of complementary in situ measurement techniques were utilized, including dynamic light scattering, ultraviolet-visible absorption spectroscopy, atomic force microscopy, and small-angle X-ray scattering, which provided a collective set of information that enabled far better understanding of the dispersion behavior in the fluid than any one technique alone. It was observed that AgNPs continued to adsorb bovine serum albumin (BSA) protein from the synthetic lung fluid solution as the sodium chloride concentration increased, until a maximum BSA coating was achieved prior to reaching the physiological sodium chloride concentration of 154 mmol L
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