期刊
NANOTOXICOLOGY
卷 5, 期 4, 页码 531-545出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/17435390.2010.530004
关键词
Mast cell; mast cell deficient mice; osteopontin; sash mice; ischemia-reperfusion injury
资金
- National Institute of Environmental Health Sciences (NIEHS) [RO1ES016246]
- NIH [RO1ES019311]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0744040] Funding Source: National Science Foundation
Cerium oxide (CeO2) represents an important nanomaterial with wide ranging applications. However, little is known regarding how CeO2 exposure may influence pulmonary or systemic inflammation. Furthermore, how mast cells would influence inflammatory responses to a nanoparticle exposure is unknown. We thus compared pulmonary and cardiovascular responses between C57BL/6 and B6.Cg-Kit(W-sh) mast cell deficient mice following CeO2 nanoparticle instillation. C57BL/6 mice instilled with CeO2 exhibited mild pulmonary inflammation. However, B6.Cg-Kit(W-sh) mice did not display a similar degree of inflammation following CeO2 instillation. Moreover, C57BL/6 mice instilled with CeO2 exhibited altered aortic vascular responses to adenosine and an increase in myocardial ischemia/reperfusion injury which was absent in B6.Cg-Kit(W-sh) mice. In vitro CeO2 exposure resulted in increased production of PGD(2), TNF-alpha, IL-6 and osteopontin by cultured mast cells. These findings demonstrate that CeO2 nanoparticles activate mast cells contributing to pulmonary inflammation, impairment of vascular relaxation and exacerbation of myocardial ischemia/reperfusion injury.
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