期刊
NANOTECHNOLOGY
卷 24, 期 19, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/0957-4484/24/19/195101
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资金
- University Grant Commission (UGC), India
- National Chemical Laboratory (CSIR-NCL), Pune
- CSIR, Govt of India
- DST, Govt of India
- Departmental Research and Development Grant, University of Pune
- University for Potential Excellence programme phase I
The resurgence of infectious diseases and associated issues related to antibiotic resistance has raised enormous challenges which may possibly be confronted primarily by nanotechnology routes. One key need of critical significance in this context is the development of an agent capable of inhibiting quorum sensing mediated biofilm formation in pathogenic organisms. In this work we examine the possible use of a nanocomposite, CdTe-TiO2, as an impeder of growth and biofilm. In the presence of CdTe-TiO2, scanning electron microscopy (SEM) analysis shows exposed cells without the surrounding matrix. Confocal laser scanning microscopy shows spatially distributed fluorescence, a typical indication of an impeded biofilm, as opposed to the control which shows matrix-covered cells and continuous fluorescence, typical of biofilm formation. Quantitatively, the inhibition of biofilm was similar to 57%. CdTe-TiO2 also exhibits good antibacterial properties against Gram positive and Gram negative organisms by virtue of the generation of reactive oxygen species inside the cells, reflected by a ruptured appearance in the SEM analysis.
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