期刊
NANOTECHNOLOGY
卷 25, 期 2, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/0957-4484/25/2/025101
关键词
magnetite; cabalt ferrite; radiolabeling; biodistribution; nanoparticles
资金
- European Commission [CP-IP 213631-2]
Metal oxide nanoparticles, hybridized with various polymeric chemicals, represent a novel and breakthrough application in drug delivery, hyperthermia treatment and imaging techniques. Radiolabeling of these nanoformulations can result in new and attractive dual-imaging agents as well as provide accurate in vivo information on their biodistribution profile. In this paper a comparison study has been made between two of the most promising hybrid core-shell nanosystems, bearing either magnetite (Fe3O4) or cobalt ferrite (CoFe2O4) cores, regarding their magnetic, radiolabeling, hyperthermic and biodistribution properties. While hyperthermic properties were found to be affected by the metal-core type, the radiolabeling ability and the in vivo fate of the nanoformulations seem to depend critically on the size and the shell composition.
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