4.6 Article

Single-base DNA discrimination via transverse ionic transport

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NANOTECHNOLOGY
卷 24, 期 41, 页码 -

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IOP PUBLISHING LTD
DOI: 10.1088/0957-4484/24/41/415101

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  1. NIH-National Human Genome Research Institute
  2. National Science Foundation
  3. US Department of Energy

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We suggest the discrimination of single DNA bases via transverse ionic transport, namely by detecting the ionic current that flows in a channel while a single-stranded DNA is driven through an intersecting nanochannel. Our all-atom molecular dynamics simulations indeed show that the ionic currents of the four bases are statistically distinct, thus offering another possible approach to sequencing DNA.

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