期刊
NANOTECHNOLOGY
卷 23, 期 40, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/0957-4484/23/40/405301
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资金
- Natural Sciences and Engineering Research Council of Canada
- Canada Foundation for Innovation
- Ontario Research Fund
We present a methodology for preparing silicon nitride nanopores that provides in situ control of size with sub-nanometer precision while simultaneously reducing electrical noise by up to three orders of magnitude through the cyclic application of high electric fields in an aqueous environment. Over 90% of nanopores treated with this technique display desirable noise characteristics and readily exhibit translocation of double-stranded DNA molecules. Furthermore, previously used nanopores with degraded electrical properties can be rejuvenated and used for further single-molecule experiments.
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