期刊
NANOTECHNOLOGY
卷 23, 期 9, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/0957-4484/23/9/095301
关键词
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资金
- National Research Foundation of Korea [2010-0000838]
- Korean Ministry of Education, Science and Technology
- National Research Foundation [2011-0002182]
- National Research Foundation of Korea [2005-2001274, 과C6A1623] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
A nanoforest structure for surface-enhanced Raman scattering (SERS) active substrates is fabricated and analyzed. The detailed morphology of the resulting structure can be easily controlled by modifying the process parameters such as initial gold layer thickness and etching time. The applicability of the nanoforest substrate as a label-free SERS immunosensor is demonstrated using influenza A virus subtype H1N1. Selective binding of the H1N1 surface antigen and the anti-H1 antibody is directly detected by the SERS signal differences. Simple fabrication and high throughput with strong in-plane hot-spots imply that the nanoforest structure can be a practical sensing component of a chip-based SERS sensing system.
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