期刊
NANOTECHNOLOGY
卷 21, 期 28, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/0957-4484/21/28/285106
关键词
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资金
- NIH [CA119397, CA119358, CA104492]
- Natural Science Foundation of China (NSFC) [60877024]
- Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP) [20090092110015]
- Nanyang Technological University
Gold nanorods (GNRs) with a longitudinal surface plasmon resonance peak that is tunable from 600 to 1100 nm have been fabricated in a cetyl trimethylammoniumbromide (CTAB) micellar medium using hydrochloric acid and silver nitrate as additives to control their shape and size. By manipulating the concentrations of silver nitrate and hydrochloric acid, the aspect ratio of the GNRs was reliably and reproducibly tuned from 2.5 to 8. The GNRs were first coated with polyelectrolyte multilayers and then bioconjugated to transferrin (Tf) to target pancreatic cancer cells. Two-photon imaging excited from the bioconjugated GNRs demonstrated receptor-mediated uptake of the bioconjugates into Panc-1 cells, overexpressing the transferrin receptor (TfR). The bioconjugated GNR formulation exhibited very low toxicity, suggesting that it is biocompatible and potentially suitable for targeted two-photon bioimaging.
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