期刊
NANOTECHNOLOGY
卷 21, 期 35, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/0957-4484/21/35/355503
关键词
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资金
- Korean government (MEST) [2010-0017105]
- Ministry of Health & Welfare of Korea [A084359]
- Ministry of Knowledge Economy of Korea [10033657]
- Inter-University Semiconductor Research Center (ISRC) at Seoul National University
- Korea Science and Engineering Foundation (KOSEF) through National Core Research Center for Nanomedical Technology [R15-2004-024-00000-0]
- KOSEF [M10755020003-08N5502-00310]
- Korea Health Promotion Institute [A084359] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
We demonstrated enhanced localized surface plasmon resonance (SPR) biosensing based on subwavelength gold nanoarrays built on a thin gold film. Arrays of nanogratings (1D) and nanoholes (2D) with a period of 200 nm were fabricated by electron-beam lithography and used for the detection of avian influenza DNA hybridization. Experimental results showed that both nanoarrays provided significant sensitivity improvement and, especially, 1D nanogratings exhibited higher SPR signal amplification compared with 2D nanohole arrays. The sensitivity enhancement is associated with changes in surface-limited reaction area and strong interactions between bound molecules and localized plasmon fields. Our approach is expected to improve both the sensitivity and sensing resolution and can be applicable to label-free detection of DNA without amplification by polymerase chain reaction.
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