期刊
NANOTECHNOLOGY
卷 21, 期 3, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/0957-4484/21/3/035101
关键词
-
资金
- DOE [DE-FG0-2O4CH11280]
- DOD [W81XWH-08-1-0305, W81XWH-05-1-0592]
Multi-color gold-nanoparticle-based tags (nanotags) are synthesized for combined surface-enhanced Raman spectroscopy (SERS) and x-ray computed tomography (CT). The nanotags are synthesized with quasi-spherical gold nanoparticles encoded with a reporter dye (color), each with a unique Raman spectrum. A library of nanotags with six different colors were synthesized for a range of gold nanoparticle sizes and an optimum size has been established to yield the largest SERS intensity and x-ray attenuation that is higher than the iodinated CT contrast agents used in clinics. Proof-of-principle in vivo imaging results with nanotags are presented that, for the first time, demonstrates the combined in vivo dual modality imaging capability of SERS and CT with a single nanoparticle probe.
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