期刊
NANOSCALE RESEARCH LETTERS
卷 4, 期 6, 页码 544-549出版社
SPRINGEROPEN
DOI: 10.1007/s11671-009-9278-x
关键词
Magnetic nanoparticles; Hydrogels; Layer-by-layer technique; Biocompatibility
资金
- National Research and Development Agency of Romania [129/2006]
Magnetic nanoparticles were obtained using an adjusted Massart method and were covered in a layer-by-layer technique with hydrogel-type biocompatible shells, from chitosan and hyaluronic acid. The synthesized nanocomposites were characterized using dynamic light scattering, transmission electron microscopy, and Fourier transformed infrared spectroscopy. Biocompatibility of magnetic nanostructures was determined by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) cell proliferation assay, swelling tests, and degradation tests. In addition, interaction of hydrogel-magnetic nanoparticles with microorganisms was studied. The possibility of precise nanoparticles size control, as long as the availability of bio-compatible covering, makes them suitable for biomedical applications.
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