期刊
NANOSCALE
卷 6, 期 6, 页码 3335-3343出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3nr06049g
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资金
- National Center for Research Resources [S10RR025631]
- National Institutes of Health [CA133697]
- Northwestern University International Institute for Nanotechnology
- Joint Center of Excellence in Integrated Nano-Systems (JCIN) at the King Abdul-Aziz City of Science and Technology (KACST) [32-942]
- Northwestern University (NU)
- [USDOD-HDTRA1-13-1-0046]
- NATIONAL CANCER INSTITUTE [R01CA133697] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [S10RR025631] Funding Source: NIH RePORTER
Two azobenzene alpha-cyclodextrin based nanovalves are designed, synthesized and assembled on mesoporous silica nanoparticles. Under aqueous conditions, the cyclodextrin cap is tightly bound to the azobenzene moiety and capable of holding back loaded cargo molecules. Upon irradiation with a near-UV light laser, trans to cis-photoisomerization of azobenzene initiates a dethreading process, which causes the cyclodextrin cap to unbind followed by the release of cargo. The addition of a bulky stopper to the end of the stalk allows this design to be reversible; complete dethreading of cyclodextrin as a result of unbinding with azobenzene is prevented as a consequence of steric interference. As a result, thermal relaxation of cis- to trans-azobenzene allows for the rebinding of cyclodextrin and resealing of the nanopores, a process which entraps the remaining cargo. Two stalks were designed with different lengths and tested with alizarin red S and propidium iodide. No cargo release was observed prior to light irradiation, and the system was capable of multiuse. On/off control was also demonstrated by monitoring the release of cargo when the light stimulus was applied and removed, respectively.
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