期刊
NANOSCALE
卷 6, 期 20, 页码 11712-11721出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4nr02570a
关键词
-
类别
资金
- European Commission [FP7-KBBE-2009-3, 245122]
- National Science Foundation CAREER Award [CMMI-1350197]
- Center for Scalable and Integrated Nano-Manufacturing [DMI-0327077]
- V Foundation for Cancer Research Scholars Award [CMMI-0856492, DMR-1343991]
- Wallace H. Coulter Foundation Translational Research Award
- Society for Laboratory Automation and Screening Endowed Fellowship
- Beckman Coulter
- National Cancer Institute [U54CA151880, 1F30CA174156]
- Northwestern University Malkin Scholarship
- Institutional Research Concept [RVO 61388971, RVO 61388963, RVO 61389005]
- CANAM infrastructure of NPI ASCR Rez through MEYS [LM2011019]
- Directorate For Engineering [1350197] Funding Source: National Science Foundation
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1343991] Funding Source: National Science Foundation
- Div Of Civil, Mechanical, & Manufact Inn [1350197] Funding Source: National Science Foundation
Nanodiamonds (NDs) are versatile nanoparticles that are currently being investigated for a variety of applications in drug delivery, biomedical imaging and nanoscale sensing. Although initial studies indicate that these small gems are biocompatible, there is a great deal of variability in synthesis methods and surface functionalization that has yet to be evaluated. Here we present a comprehensive analysis of the cellular compatibility of an array of nanodiamond subtypes and surface functionalization strategies. These results demonstrate that NDs are well tolerated by multiple cell types at both functional and gene expression levels. In addition, ND-mediated delivery of daunorubicin is less toxic to multiple cell types than treatment with daunorubicin alone, thus demonstrating the ability of the ND agent to improve drug tolerance and decrease therapeutic toxicity. Overall, the results here indicate that ND biocompatibility serves as a promising foundation for continued preclinical investigation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据