期刊
NANOSCALE
卷 6, 期 13, 页码 7325-7331出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4nr00460d
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资金
- Dr Alfred Bretscher Fund
- Swiss National Science Foundation [PP00P2-123373/1]
- Adolphe Merkle Foundation
- University of Fribourg
- Swiss National Science Foundation through the National Centre of Competence in Research Bio-Inspired Materials
Agglomeration of nanoparticles in biological fluids is a pervasive phenomenon that leads to difficulty in the interpretation of results from in vitro exposure, primarily due to differing particokinetics of agglomerates to nanoparticles. Therefore, well-defined small agglomerates were designed that possessed different particokinetic profiles, and their cellular uptake was compared to a computational model of dosimetry. The approach used here paves the way for a better understanding of the impact of agglomeration on the nanoparticle-cell interaction.
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