期刊
NANOSCALE
卷 6, 期 8, 页码 4361-4370出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3nr06160d
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资金
- National Natural Science Foundation of China [21171035, 51302035]
- Key Grant Project of Chinese Ministry of Education [313015]
- PhD Programs Foundation of the Ministry of Education of China [20110075110008, 20130075120001]
- National 863 Program of China [2013AA031903]
- Science and Technology Commission of Shanghai Municipality [13ZR1451200]
- Fundamental Research Funds for the Central Universities
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1221]
- Shanghai Leading Academic Discipline Project [B603]
- Program of Introducing Talents of Discipline to Universities [111-2-04]
A low-toxic difunctional nanoplatform integrating both photothermal therapy and chemotherapy for killing cancer cells using Cu2-xSe@mSiO(2)-PEG core-shell nanoparticles is reported. Silica coating and further PEG modification improve the hydrophilicity and biocompatibility of copper selenide nanoparticles. As-prepared Cu2-xSe@mSiO(2)-PEG nanoparticles not only display strong near infrared (NIR) region absorption and good photothermal effect, but also exhibit excellent biocompatibility. The mesoporous silica shell is provided as the carrier for loading the anticancer drug, doxorubicin (DOX). Moreover, the release of DOX from Cu2-xSe@mSiO(2)-PEG core-shell nanoparticles can be triggered by pH and NIR light, resulting in a synergistic effect for killing cancer cells. Importantly, the combination of photothermal therapy and chemotherapy driven by NIR radiation with safe power density significantly improves the therapeutic efficacy, and demonstrates better therapeutic effects for cancer treatment than individual therapy.
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