期刊
NANOSCALE
卷 6, 期 21, 页码 12849-12855出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4nr04064c
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资金
- RCB
- IISER
- NII
- Department of Biotechnology, Govt. of India
- DST
- IISER Bhopal
The majority of the localized drug delivery systems are based on polymeric or polypeptide scaffolds, as weak intermolecular interactions of low molecular weight hydrogelators (LMHGs, M-w <500 Da) are significantly perturbed in the presence of anticancer drugs. Here, we present L-alanine derived low molecular weight hydrogelators (LMHGs) that remain injectable even after entrapping the anticancer drug doxorubicin (DOX). These DOX containing nanoassemblies (DOX-Gel) showed promising anticancer activity in mice models. Subcutaneous injection of DOX-Gel near the tumor achieved a greater decrease in tumour load than by intravenous injection of DOX (DOX-IV), and local injection of DOX alone (DOX-Local) at the tumor site. We noticed that DOX-Gel nanocarriers are especially effective when injected during the early stage of tumor progression, and achieve a substantial decrease in tumor load in the long term.
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