期刊
NANOSCALE
卷 6, 期 21, 页码 13036-13042出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4nr03210a
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资金
- National Basic Research Program of China (973 program) [2012CB933301, 2011CB309501]
- National Natural Science Foundation of China [61321492, 91323304, 91123037, 81402468, 81201358]
- FP-7 PEOPLE-IRSES project ECNANOMAN [269219]
- Shanghai International Science and Technology Cooperation Foundation project [12410707300]
- Shanghai Youth Science and Technology Talent Sailing project [14YF1407200]
Sensitive and quantitative analysis of proteins is central to disease diagnosis, drug screening, and proteomic studies. Here, a label-free, real-time, simultaneous and ultrasensitive prostate-specific antigen (PSA) sensor was developed using CMOS-compatible silicon nanowire field effect transistors (SiNW FET). Highly responsive n- and p-type SiNW arrays were fabricated and integrated on a single chip with a complementary metal oxide semiconductor (CMOS) compatible anisotropic self-stop etching technique which eliminated the need for a hybrid method. The incorporated n- and p-type nanowires revealed complementary electrical response upon PSA binding, providing a unique means of internal control for sensing signal verification. The highly selective, simultaneous and multiplexed detection of PSA marker at attomolar concentrations, a level useful for clinical diagnosis of prostate cancer, was demonstrated. The detection ability was corroborated to be effective by comparing the detection results at different pH values. Furthermore, the real-time measurement was also carried out in a clinically relevant sample of blood serum, indicating the practicable development of rapid, robust, high-performance, and low-cost diagnostic systems.
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