期刊
NANOSCALE
卷 6, 期 10, 页码 5116-5120出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3nr06590a
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资金
- National Basic Research Program of China (973 Program) [2012CB825800, 2013CB932702]
- National Natural Science Foundation of China (NSFC) [51132006]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Suzhou Planning Project of Science and Technology [ZXG2012028]
The interaction between carbon quantum dots (CQDs) and a single living cell was explored in real time. Here, we provide the quantitative data on the permeability of the HeLa cell membrane in the presence of CQDs with different surface functional groups (CQDs terminated with -OH/-COOH (CQD-OH), -PEG (CQD-PEG), and -NH2 (CQD-NH2)). Although these CQDs have very low toxicity towards HeLa cells, they still increase the cell membrane permeability by 8%, 13%, and 19% for CQD-PEG, CQD-OH, and CQD-NH2, respectively, and this kind of permeability was irreversible. These observations are valuable for promoting the bio-applications of carbon nanostructures in living systems.
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