期刊
NANOSCALE
卷 6, 期 22, 页码 13701-13709出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4nr04054f
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资金
- Chinese Natural Science Foundation [81171455, 81272453, 81271476, 31170873]
- National Natural Science Foundation of China [31225009]
- National Key Basic Research Program of China [2009CB930200]
- Chinese Academy of Sciences (CAS) Hundred Talents Program [07165111ZX]
- CAS Knowledge Innovation Program
- State High-Tech Development Plan [2012AA020804]
To address current medical challenges, there is an urgent need to develop drug delivery systems with multiple functions, such as simultaneous stimuli-responsive drug release and real-time imaging. Biocompatible polymers have great potential for constructing smart multifunctional drug-delivery systems through grafting with other functional ligands. More importantly, novel biocompatible polymers with intrinsic fluorescence emission can work as theranostic nanomedicines for real-time imaging and drug delivery. Herein, we developed a highly fluorescent nanoparticle based on a phenylboronic acid-modified poly(lactic acid) poly(ethyleneimine)(PLA-PEI) copolymer loaded with doxorubicin (Dox) for intracellular imaging and pH-responsive drug delivery. The nanoparticles exhibited superior fluorescence properties, such as fluorescence stability, no blinking and excitation-dependent fluorescence behavior. The Dox-loaded fluorescent nanoparticles showed pH-responsive drug release and were more effective in suppressing the proliferation of MCF-7 cells. In addition, the biocompatible fluorescent nanoparticles could be used as a tool for intracellular imaging and drug delivery, and the process of endosomal escape was traced by real-time imaging. These pH-responsive and biocompatible fluorescent polymer nanoparticles, based on phenylboronic acid, are promising tools for intracellular imaging and drug delivery.
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