期刊
NANOSCALE
卷 5, 期 24, 页码 12120-12125出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3nr04056a
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资金
- National High Technology Research and Development Program of China (863 Program) [2007AA021107]
- Program for New Century Excellent Talents in University [39015001200801]
- MOST 973 program [2010CB934004]
- NSFC [81272453]
We report an innovative approach for miRNA-203 delivery in esophageal cancer cells using protamine sulphate (PS)-nanodiamond (ND) nanoparticles. The efficient delivery of miR-203 significantly suppressed the proliferation and migration of cancer cells through targeting Ran and DNp63, exhibiting a great potential for PS@ND nanoparticles in miRNA-based cancer therapy.
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