期刊
NANOSCALE
卷 5, 期 17, 页码 8098-8104出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3nr02797j
关键词
-
类别
资金
- Major State Basic Research Development Program of China (973 Program) [2013CB733802]
- National Science Foundation of China (NSFC) [81101101, 51273165, 81201086, 81201190]
- Key Project of Chinese Ministry of Education [212149]
- Fundamental Research Funds for the Central Universities [2013121039]
- National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
This report illustrates a new strategy of designing a T-1-T-2 dual-modal magnetic resonance imaging (MRI)-visible vector for siRNA delivery and MRI. Hydrophobic gadolinium embedded iron oxide (GdIO) nanocrystals are self-assembled into nanoclusters in the water phase with the help of stearic acid modified low molecular weight polyethylenimine (stPEI). The resulting water-dispersible GdIO-stPEI nanoclusters possess good stability, monodispersity with narrow size distribution and competitive T-1-T-2 dual-modal MR imaging properties. The nanocomposite system is capable of binding and delivering siRNA for knockdown of a gene of interest while maintaining its magnetic properties and biocompatibility. This new gadolinium embedded iron oxide nanocluster provides an important platform for safe and efficient gene delivery with non-invasive T-1-T-2 dual-modal MRI monitoring capability.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据