期刊
NANOSCALE
卷 5, 期 14, 页码 6249-6253出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3nr00227f
关键词
-
类别
资金
- Beijing area major laboratory of peptide and small molecular drugs
- PHR (IHLB)
- NSFC [21171120, 81172930]
- Beijing Natural Science Foundation [7132020]
- Project for Science and Technology Development, Beijing Commission of Education [SQKM201210025007]
Mesoporous silica nanoparticles with amino and thiol groups (MSNSN) were prepared and covalently modified with methotrexate and 6-mercaptopurine to form 6-MP-MSNSN-MTX. In the presence of DTT, 6-MP-MSNSN-MTX gradually releases 6-MP. In rat plasma, 6-MP-MSNSN-MTX effectively inhibits the metabolic deactivation of 6-MP and MTX. 6-MP-MSNSN-MTX could be an agent for long-acting chemotherapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据