Graphene oxide strongly inhibits amyloid beta fibrillation

Since amyloid beta fibrillation (AbF) plays an important role in the development of neurodegenerative diseases, we investigated the effect of graphene oxide (GO) and their protein-coated surfaces on the kinetics of Ab fibrillation in the aqueous solution. We showed that GO and their protein-covered surfaces delay the AbF process via adsorption of amyloid monomers. Also, the large available surface of GO sheets can delay the AbF process by adsorption of amyloid monomers. The inhibitory effect of the GO sheet was increased when we increase the concentration from 10% (in vitro; stimulated media) to 100% (in vivo; stimulated media). Conclusion: our results revealed that GO and their surface proteins inhibit AbF by decreasing the kinetic reaction.