期刊
NANOSCALE
卷 4, 期 13, 页码 3843-3851出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2nr30467h
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资金
- National Institutes of Health [GM 076479, RC2DA028981]
- Defense Threat Reduction Agency [HDTRA1-09-0013]
- Vanderbilt Institute for Nanoscale Science Engineering
- Vanderbilt College of Arts and Sciences
- Vanderbilt Institute of Chemical Biology
- Vanderbilt Institute for Integrative Biosystems Research and Education
Gold nanoparticles (AuNPs) protected by self-assembled monolayers (SAMs) are capable of presenting precisely engineered surfaces at the nanoscale, allowing the mimicry of biomacromolecules on an artificial platform. Here we review the generation, characterization, and applications of monolayer-protected AuNPs that have been designed for immunorecognition by the integration of an oligopeptide epitope into the protecting monolayer. The resulting peptide-AuNP conjugate is an effective platform for biomimesis, as demonstrated by multiple studies. Recent work is presented and future directions for this field of research are discussed.
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