期刊
NANOSCALE
卷 3, 期 6, 页码 2454-2457出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1nr10218d
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资金
- National Basic Research Program of China [2011CB933600]
- Chinese Academy of Sciences [KJCX2-YW-M15, KSCX2-EW-Q-15]
The fluorescence labeling of viruses is a useful technology for virus detection and imaging. By combining the excellent fluorescence properties of quantum dots (QDs) with the high affinity and specificity of aptamers, we constructed a QD-aptamer probe. The aptamer A22, against the hemagglutinin of influenza A virus, was linked to QDs, producing the QD-A22 probe. Fluorescence imaging and transmission electron microscopy showed that the QD-A22 probe could specifically recognize and label influenza A virus particles. This QD labeling technique provides a new strategy for labeling virus particles for virus detection and imaging.
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