期刊
NANOSCALE
卷 3, 期 5, 页码 2003-2008出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0nr01018a
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资金
- National Institutes of Health [R01CA119358, RO1CA104492]
- Swedish Energy Agency [32076-1]
- John R. Oishei Foundation
- NATIONAL CANCER INSTITUTE [R01CA119358, R01CA104492] Funding Source: NIH RePORTER
We report core/shell NaYbF4 : Tm3+/NaGdF4 nanocrystals to be used as probes for bimodal near infrared to near infrared (NIR-to-NIR) upconversion photoluminescence (UCPL) and magnetic resonance (MR) imaging. The NaYbF4 : Tm3+ nanocrystals were previously reported to produce the intense NIR-to-NIR UCPL peaked at similar to 800 nm under excitation at similar to 975 nm. We have found that the growth of a NaGdF4 shell on surface of the NaYbF4 : Tm3+ nanocrystals results in the increase in the intensity of UCPL of Tm3+ ions by about 3 times. Unlike biexponential PL decay of NaYbF4 : Tm3+ nanocrystals, the PL decay of NaYbF4 : Tm3+/NaGdF4 core/shell nanocrystals is single exponential and of longer lifetime due to the suppression of surface quenching effects for Tm3+ PL. The growth of a NaGdF4 shell on surface of the NaYbF4 : Tm3+ nanocrystals also provides high MR relaxivity from paramagnetic Gd3+ ions contained in the shell. The T1-weighted MR signal of the (NaYbF4:2% Tm3+)/NaGdF4 nanoparticles was measured to be about 2.6 mM(-1)s(-1). Due to the combined presence of efficient optical and MR imaging capabilities, nanoprobes based on NaYbF4 : Tm3+/NaGdF4 fluoride nanophosphors can be considered as a promising platform for simultaneous bimodal PL and MR bioimaging.
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