期刊
NANOSCALE
卷 3, 期 9, 页码 3888-3892出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1nr10617a
关键词
-
类别
资金
- National Basic Research Program of China [2007CB936000]
- Chinese Academy of Sciences [KJCX2-EW-N03]
- National Science Foundation of China [10975175, 90923002, 90923041]
- Max Planck Society
Investigation into the interactions between graphene oxide (GO) and biomolecules is very important for broad applications of GO in bioassay and bioanalysis. In this work, we describe the interactions between double-stranded DNA (dsDNA) and GO. We demonstrated that dsDNA can bind to GO forming complexes (dsDNA/GO) in the presence of certain salts, which protects dsDNA from being enzymatically digested. On the other hand, we found that a nonionic surfactant, such as triton X-100, can block the formation of dsDNA/GO complexes, so that the enzymatic digestion of dsDNA is restored. These results lead us to believe that the reason for GO protecting dsDNA from enzymatic digestion is the formation of dsDNA/GO complexes hindering the access of DNA enzymes to dsDNA, rather than direct inactivation of the DNA enzymes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据