期刊
NANOSCALE
卷 2, 期 1, 页码 114-121出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b9nr00130a
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资金
- US EPA [R833323]
- National Science and Engineering Research Council of Canada (NSERC)
- Canada Research Chairs
- DOE BES [DE-AC02-06CH11357]
CdSe/ZnS quantum clots (QDs) conjugated to biomolecules that can act as electron donors are said to be photosensitized: that is, they are able to oxidize or reduce molecules whose redox potential lies inside their band edges, in particular molecular oxygen and water. This leads to the formation of reactive oxygen species (ROS) and phototoxicity. In this work, we quantify the generation of different forms of ROS from as-synthesized QDs in toluene; water-solubilized, unconjugated QDs; QDs conjugated to the neurotransmitter dopamine; and dopamine alone. Results of indirect fluorescent ROS assays, both in solution and inside cells, are compared with those of spin-trap electron paramagentic resonance spectroscopy (EPR). The effect of these particles on the metabolism of mammalian cells is shown to be dependent upon light exposure and proportional to the amount of ROS generated.
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